This is a list of people who went missing after the year 2000 and people whose locations are unknown or whose deaths have not been confirmed, except for those who disappeared at sea. Many people who go missing are later declared dead without being present, but the exact dates and reasons for their deaths are still unknown. In some cases, people may have been taken against their will, but there is not enough information about what happened to them in many situations.

Global data about missing people from the late 20th and early 21st centuries is not always accurate. This is because of factors such as international movement, the ability to travel, and legal protections for people who may have intentionally disappeared. According to the International Commission on Missing Persons, "There is little complete and accurate information about how many people go missing worldwide because of trafficking, violence related to drugs, or migration. Even the numbers of people missing because of wars or human rights violations, which are more closely watched, are hard to confirm because most countries are not willing to share honest or complete information about these issues."

By the mid-1990s in the United States, there were nearly 1 million missing persons cases. This number dropped by about half by 2021. As of 2014, about 90,000 people in the United States were missing at any given time, with about 60% being adults and 40% being children. In 2021, there were about 520,000 missing person cases in the United States. A 2017 report showed that the states of Oregon, Arizona, and Alaska had the highest number of missing person cases per 100,000 people. In Canada, which has a population about one-tenth the size of the United States, there are fewer missing person cases overall, but the rate per person is higher. In 2015, about 71,000 missing person cases were reported in Canada. Of these, 88% were found within seven days, but about 500 people remained missing after one year. In the United Kingdom, it was estimated in 2009 that about 275,000 British people go missing each year. In some countries, such as Japan, the number of missing people is not fully known because many cases are not reported to authorities.